Search results for " impeller"
Article
What’s New in Upstream Technologies
“We’ve developed a dual impeller SUB configuration to improve mixing efficiency and provide higher kLa values to support our customers as they develop tomorrow’s medicines and cures.”
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Downstream Processing for Cell-Based Therapies
…ciation reagent (such as recombinant trypsin) and some physical force exerted through an increase in impeller agitation, bioreactor rotation, or increased flow rates depending on the culture vessel e…
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Mixing dynamics in a large volume single use mixer
Dispersion and settling were evaluated as part of this study, which provides a clear decision path on the tank shape and impeller quantity for a given impeller design and a given impeller location. D…
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Modeling Bioreactor Performance
Challener
Bioreactor design, including the geometry of the tank and impeller and the locations of inlets, has a direct impact on the performance of cell-culture and fermentation processes. Modelin…
Article
The use of Xcellerex™ mixing system as slurry tank when packing chromatography columns
The system is complete with motor and controls, and an irradiated USP Class VI, single-use, low-density polyethylene plastic bag equipped with a disposable bottom-mounted impeller. The connection betw…
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
The mechanical shear forces from the impeller and the oxidative stresses caused by a large amount of dispersed bubbles can also be harmful to the cells. Mixing is more efficient at small scale than at…
Article
Tools for Continuous Bioprocessing Development
…w-well microtiter plates; deep-well microtiter plates; shake flasks; benchtop bioreactors of various impeller and sparger designs with various culture volumes and larger bioreactors of various impell…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
For instance, Cytiva has introduced subtle modifications to existing bioreactor platforms such as improved impeller and baffle designs and the use of different gas sparging sizes to increase transfect…
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Cell-Culture Advances Test Bioreactor Performance Models
Shear issues in single-use bioreactors
The shift to single-use technologies has also introduced a wider diversity of bioreactor designs, particularly with respect to spargers, baffles, and impel…
Article
Achieving Process Balance with Perfusion Bioreactors
“It is not just the design of the biocontainers, but also the impellers and aerator that can have a great impact on how the cells are handled in the process,” he explains. There have been bioreactor b…